4/13/08. A  new page on low-dose glucocorticoids(hydrocortisone, prednisone, dexamethasone and triamcinolone) has been added. It is linked off the 2nd line hormone therapy page.

4/13/08. A new page on triamcinolone has been added.

4/4/08. The page on mitoxantrone was updated with a paper on mitoxantrone + ketoconazole + gm-csf(leukine) in table 2.

2/25/08. The page on aminoglutethimide was updated with information from a paper by Kruit WJ et al, 2004 which shows good results based on PSA.

2/16/2008. A new page on gemcitabine (Gemzar) has been written. Studies that have some impact on HRPC disease are discussed and summarized in tables.

2/12/2008. A new page on vinorelbine(Navelbine) was added.

12/18/2007. A  new page on Revlimid (lenalidomide) has been added. It has recent data on its use with leukine and taxotere as well as toxicity data from phase I trials.

11/7/2007. The page on ONJ was updated.

10/19/2007. A paper on using Valproic Acid (Depakote ER) for HRPC has been added.  This use must still be proven, but the drug is already available.

10/1/07. Information on ONJ was put onto its own page.

8/1/07. A Presentation on A Personal Experience with Clinical Trials by Ian Liston has been added to the Clinical Trials Resources Page.

7/29/07. The chemotherapy-other (than taxanes) page has been updated.  A  number of studies using cyclophosphamide were added plus others from ASCO 2007.

7/26/07. Fatigue pages updated (use of ginseng, modafinal).

7/04/07. A new page on Satraplatin was added. This primarily covers the phase III SPARC clinical trial results. Also the outcome of the ODAC meeting on 7/24/07 was added to this page (complete the full survival analysis 1st.)

6/25/07. A new page reviewing HRPC clinical trials for Ixabepilone was added. This is linked off the Potential Treatments page which has also been revised.

6/24/07. A page with anecdotal reports from patients dealing with nail/skin toxicity was added.  Also added is a page containing reports from patients on their experiences with chemo ports.

6/21/07. The page on glutamine for prevention of peripheral neuropathy has been updated. A new page containing all the information on nail/skin and peripheral neuropathy toxicities was created. 

3/27/07. A new page on adding dutasteride after "failing" ketoconazole delaying progression was added linked off the "Other" page.

3/18/07.  A  new page was created covering proven treatments - other linked from the proven treatments page.

3/17/07.  The current information on Satraplatin was added to the Potential Treatments page.

3/7/07. An over-counter-medicine, Noscapine, was added to the Potential treatments page.

2/17/07. Updated the lymphedema page and also added a link to a PDF version of the paper, "Lymphedema" by P. O'Brien, M.D. (1.3MB).

2/14/07. Added a page on the Bone Scan with an example which adds to the information on the diagnostics page.

2/13/07. Updated Bisphosphonates with information/links on ONJ and also some clarification on half-life of Zometa.

2/10/07. Updated information resources page with nutrition and cancer links.

2/8/07. Updated Fatigue with new L-Carnitine Results.

2/6/07. Updated Diagnostic Tests.

2/5/07. Updated Abraxane page with information on another metastatic breast cancer trial.

1/24/07. A new paper on mitoxantrone as a 2nd-line chemotherapy was added. Is Mitoxantrone a Viable 2nd-line chemotherapy for hrpc? And What Might be Added to improve its response rate? by H.Hansen.

1/12/07. Added another reference to FAQ.htm -- A6 on PSA flare phenomenon on taxotere.

1/5/07. A new paper on Xeloda(capecitabine) either by itself or in combination with taxotere (author: Howard Hansen).

4/16/06. Updated Exisulind page.

4/10/2006. A new page, Taxol Combinations Including Taxol and High Dose Calcitriol was added.  This incorporates what is known about taxol plus high dose calcitriol.

3/19/2005. A new page, chemotherapy updates,  containing links to the 2004 Chemotherapy Update and links to 4 new pages with the update tables beginning with 2005.  The new tables cover taxotere, taxol, studies that had prior chemotherapy and an other category.

1/23/06 Chapter 15, Managing Chemotherapy Side Effects has been added to the booklet.

1/19/06 An article on Phenoxodiol was added to the list of  potential treatments.

12/30/05 A list of patient travel resources was added to the "Information Resources" page.

10/20/05. An article on Abraxane^TM , albumin nanoparticle paclitaxel (Taxol) added to the chemotherapy home age.

9/17/05 The page on Leukine was updated to include the combination of leukine and ketoconazole.

9/17/05 A new page on somatostatin analogs has been added (octreotide, lanreotide with dexamethasone or estrogens).

8/4/05 Chapter 14 on chemotherapy has been added to the booklet.

7/28/05  Chapter 12 added to the booklet.

6/10/05  A new page dealing with mouth sores (mucositis) has been added. This is based on various patient's inputs.

5/18/05  Jack Beaven's continues his updates of what has happened since his Provenge vaccine trial participation in Since Provenge Part II.

5/14/05 A new handbook for hrpca patients (A Handbook: Living With Advanced Prostate Cancer), can be ordered through the Prostate-Cancer Research Institute(PCRI.) They have a web page with information on how to obtain the handbook from them.

2/5/2005 A new page on chemotherapy -- an update of 2004 ASCO abstracts and 2004 papers as well as some earlier papers which are included as references.  Update of Chemotherapy for 2004 - Part I. Taxanes and Mitoxantrone

12/12/04 A new page on Depression (Distress) was added that also contains a table of antidepressant drugs (Mood Elevators).

12/9/04 A search capability was added. Google is used and the search box is at the bottom of the 1st page. The primary website name is now hrpca.org and hormonerefractorypca.org is the secondary name.

11/3/04 Intermittent Chemotherapy -- Leukine, Retinoids and Thalidomide for Extending the Off Period. This paper discusses a possible way of reducing the side effects of chemotherapy. The drugs discussed might also be useful in the context of 2nd line hormone therapy.

11/2/04 FAQ updated with PSADT information.

7/24/04 Ketoconazole page updated with side effects and using ketoconazole with chemotherapy.

7/6/04 Aptosyn - page updated to reflect purchase by OSI Pharmaceuticals.

7/1/04 After Provenge. An account of a patients status following a phase III Provenge clinical trial.

7/1/04 A single patient case study comparing Modafinil and Methylphenidate for combating chemotherapy induced fatigue.

4/13/04 Acronyms page added. This lists acronyms unique to this website and links to other web resources for glossary information and acronyms definitions.

2/19/04 An article on Lymphedema has been added.

2/19/04 Updates were made to FAQ(FAQ#2 added), Chemotherapy and Symptoms Management pages. Also minor updates made in other pages.

2/6/04 Aishman's writeup of glutamine for peripheral neuropathy was moved from the chemotherapy page to a separate page. It is still also found in Aishman's part 2 paper.

1/28/04. Tables have been added to radiation therapy for hrpca patients that explain when to use radiopharmaceuticals and when not to.

1/26/04. An explanation of the complete blood count(CBC) was added.

11/22/03. Blood-clotting - A Common, but Dangerous, Cancer Side Effect was added to the "symptoms management" page.

10/5/03. Taxol or Taxotere? A comparison of  these two chemotherapy drugs from a patient 'friendliness' point of view. Bill Aishman, March, 2003.

10/5/03. Epothilones(epothilone B or BMS-247550. EPOTHILONE B-- A NEW, EFFECTIVE CHEMOTHERAPY DRUG FOR ADVANCED PROSTATE CANCER IN OUR LIFETIME? Bill Aishman, September, 2003.

10/05/03.  Velcade: the Magic Bullet for Cancer? A prostate cancer patient’s overview of an exciting new cancer drug in development and trial. Bill Aishman September 2003.

7/20/03 MoAbs - A Personal Experience With a Targeted Chemotherapy Clinical Trial (MLN2704).

7/20/2003 Calcitriol as an Antitumor Agent and Enhancer of Chemotherapy Agents - A Patients Perspective. July 2003. This includes the high dose pulsed administration with taxotere (Beer et al).

3/12/03 Vaccine Page for Provenge updated to indicate Jack had been on placebo arm.

2/8/03 A new navigation - link bar implemented, various pages with minor updates and all links verified.

2/8/03 A new page on liver function tests with an example of a liver function panel added. Also a new page on kidney functions has been added.

1/03/03 A new page with all the second line hormone therapies was added.

12/28/02 The old exisulind page was replaced with a new Aptosyn® page.  This provides an update on this drug.

12/13/02 Revised Bone Integrity page; added a bisphosphonates page with detailed information on Zometa

11/27/02 Added a page on Aminoglutethimide as a second line hormone treatment.

11/26/02 Added a page of links to prostate cancer websites, including general cancer and some related websites.

11/18/02 Update of Provenge vaccine trial; a minor modification to the "Estrogens" section on DES.

10/14/02 Seminars in Urologic Oncology - Recent reports re Prostate Cancer. This is a review of Seminars in Urologic Oncology, Volume 20, No. 3, Supplment 1 (August), 2002 which is devoted to prostate cancer.

10/14/02 Effexor for Treating the Pain of Peripheral Neuropathy.

10/14/02 Peripheral Neuropathy (polyneuropathy)... a common side-effect of chemotherapy--is there any solution? Written by Bill Aishman

8/12/02. Clinical Trials -- Should we Participate?

7/17/02. Combined Hormonal Ablation/Chemotherapy for High Risk Prostate Cancer

7/11/02. A presentation given by Charles E. Myers, MD to the Kettering Medical Center Prostate Cancer Support Group on 4/25/02 has been added.

7/7/02. An example of impact of taxotere followed by Novantrone on white blood cell count(WBC) and granulocytes.

7/5/02. A Booklet about HRPCa - 7 chapters done so far.

5/28/02. ASCO 2002 (A Patient's View)

4/2002. Radiation Therapy for HRPCA - spot radiation and radiopharmaceuticals

4/2002. DES and Other Estrogens

3/2002. Thinking Out-of-the-Box.  A patient’s musings about whether our conventional treatment for advanced prostate cancer with chemotherapy can be modified to prolong quality survival.

2/2002. Nonsteriodal Anti-Inflammatory Drugs in the Treatment of Prostate Cancer

VEGF and Radiation Therapy

Evaluations of Potential New Therapies for HRPC

Pain Control for HRPC

2/2002. Can Chemotherapy Extend Survival for HRPC?

A Patients Perspective on Chemotherapy, Part 2

A Patients Perspective on Chemotherapy, Part 1