4/13/08. A new page on
prednisone, dexamethasone and
triamcinolone) has been
added. It is linked off the
2nd line hormone therapy page.
4/13/08. A new page on
triamcinolone has been added.
4/4/08. The page on
mitoxantrone was updated with a paper on
mitoxantrone + ketoconazole + gm-csf(leukine) in table 2.
2/25/08. The page on
aminoglutethimide was updated with information from
a paper by Kruit WJ et al, 2004 which shows good results
based on PSA.
2/16/2008. A new page on
gemcitabine (Gemzar) has been written. Studies that
have some impact on HRPC disease are discussed and
summarized in tables.
2/12/2008. A new page on
vinorelbine(Navelbine) was added.
12/18/2007. A new page on Revlimid (lenalidomide)
has been added. It has recent data on its use with leukine and taxotere as well as toxicity data from phase
11/7/2007. The page on
ONJ was updated.
10/19/2007. A paper on using
Valproic Acid (Depakote ER) for HRPC has been
added. This use must still be proven, but the drug is
10/1/07. Information on
ONJ was put onto its own page.
8/1/07. A Presentation on
A Personal Experience with Clinical Trials by Ian
Liston has been added to the
Clinical Trials Resources Page.
chemotherapy-other (than taxanes) page has been
updated. A number of studies using cyclophosphamide
were added plus others from ASCO 2007.
Fatigue pages updated (use of
7/04/07. A new page on
Satraplatin was added. This primarily covers the
phase III SPARC clinical trial results. Also the outcome
of the ODAC meeting on 7/24/07 was added to this page
(complete the full survival analysis 1st.)
6/25/07. A new page reviewing HRPC clinical trials for
Ixabepilone was added. This is linked off the
Potential Treatments page which has also been
6/24/07. A page with anecdotal reports from patients
nail/skin toxicity was added. Also added is a page
containing reports from patients on their experiences
6/21/07. The page on
glutamine for prevention of peripheral neuropathy
has been updated. A new page containing all the
nail/skin and peripheral neuropathy toxicities was
3/27/07. A new page on adding
dutasteride after "failing" ketoconazole delaying
progression was added linked off the "Other" page.
3/18/07. A new page was created covering
proven treatments - other linked from the proven
3/17/07. The current information on Satraplatin was
added to the
Potential Treatments page.
3/7/07. An over-counter-medicine, Noscapine, was added
Potential treatments page.
2/17/07. Updated the
lymphedema page and also added a link to a PDF
version of the paper, "Lymphedema"
by P. O'Brien, M.D. (1.3MB).
2/14/07. Added a page on the
Bone Scan with an example which adds to the
information on the diagnostics page.
Bisphosphonates with information/links on ONJ and
also some clarification on half-life of Zometa.
information resources page with nutrition and cancer
Fatigue with new L-Carnitine Results.
Abraxane page with information on another metastatic
breast cancer trial.
1/24/07. A new paper on mitoxantrone as a 2nd-line
chemotherapy was added.
Is Mitoxantrone a Viable 2nd-line chemotherapy for hrpc?
And What Might be Added to improve its response rate?
1/12/07. Added another reference to FAQ.htm -- A6 on PSA
flare phenomenon on taxotere.
1/5/07. A new paper on
Xeloda(capecitabine) either by itself or in
combination with taxotere (author: Howard Hansen).
4/10/2006. A new page,
Taxol Combinations Including Taxol and High Dose
Calcitriol was added. This incorporates what is
known about taxol plus high dose calcitriol.
3/19/2005. A new page,
chemotherapy updates, containing links to the 2004
Chemotherapy Update and links to 4 new pages with the
update tables beginning with 2005. The new tables cover
taxotere, taxol, studies that had prior chemotherapy and
an other category.
Chapter 15, Managing Chemotherapy Side Effects has
been added to the
1/19/06 An article on
Phenoxodiol was added to the list of potential
12/30/05 A list of
patient travel resources was added to the
"Information Resources" page.
10/20/05. An article on
AbraxaneTM , albumin nanoparticle
paclitaxel (Taxol) added to the chemotherapy home age.
9/17/05 The page on
Leukine was updated to include the combination of
leukine and ketoconazole.
9/17/05 A new page on
somatostatin analogs has been added (octreotide,
lanreotide with dexamethasone or estrogens).
Chapter 14 on chemotherapy has been added to the
Chapter 12 added to the booklet.
6/10/05 A new page dealing with
mouth sores (mucositis) has been added. This is
based on various patient's inputs.
5/18/05 Jack Beaven's continues his updates of what has
happened since his Provenge vaccine trial participation
Since Provenge Part II.
new handbook for hrpca patients (A Handbook: Living With
Advanced Prostate Cancer), can be ordered through the
Prostate-Cancer Research Institute(PCRI.) They have a
web page with information on
how to obtain the handbook from them.
2/5/2005 A new page on chemotherapy -- an update of 2004
ASCO abstracts and 2004 papers as well as some earlier
papers which are included as references.
Update of Chemotherapy for 2004 - Part I. Taxanes and
12/12/04 A new page on
Depression (Distress) was added that also contains a
table of antidepressant drugs (Mood Elevators).
12/9/04 A search capability was added. Google is used
and the search box is at the bottom of the 1st page. The
primary website name is now hrpca.org and
hormonerefractorypca.org is the secondary name.
Intermittent Chemotherapy -- Leukine, Retinoids and
Thalidomide for Extending the Off Period. This paper
discusses a possible way of reducing the side effects of
chemotherapy. The drugs discussed might also be useful
in the context of 2nd line hormone therapy.
11/2/04 FAQ updated with PSADT information.
Ketoconazole page updated with side effects and
using ketoconazole with chemotherapy.
Aptosyn - page updated to reflect purchase by OSI
After Provenge. An account of a patients status
following a phase III Provenge clinical trial.
A single patient case study comparing Modafinil and
Methylphenidate for combating chemotherapy induced
Acronyms page added. This lists acronyms unique to
this website and links to other web resources for
glossary information and acronyms definitions.
2/19/04 An article on
Lymphedema has been added.
2/19/04 Updates were made to
Symptoms Management pages. Also minor updates made
in other pages.
2/6/04 Aishman's writeup of
glutamine for peripheral neuropathy was moved from
the chemotherapy page to a separate page. It is still
also found in Aishman's part 2 paper.
1/28/04. Tables have been added to
radiation therapy for hrpca patients that explain
when to use radiopharmaceuticals and when not to.
1/26/04. An explanation of the
complete blood count(CBC) was added.
Blood-clotting - A Common, but Dangerous, Cancer Side
Effect was added to the "symptoms management" page.
Taxol or Taxotere? A comparison of these two
chemotherapy drugs from a patient 'friendliness' point
of view. Bill Aishman, March, 2003.
10/5/03. Epothilones(epothilone B or BMS-247550.
EPOTHILONE B-- A NEW, EFFECTIVE CHEMOTHERAPY DRUG FOR
ADVANCED PROSTATE CANCER IN OUR LIFETIME? Bill
Aishman, September, 2003.
Velcade: the Magic Bullet for Cancer? A prostate cancer
patient’s overview of an exciting new cancer drug in
development and trial. Bill Aishman September 2003.
7/20/03 MoAbs -
A Personal Experience With a Targeted Chemotherapy
Clinical Trial (MLN2704).
Calcitriol as an Antitumor Agent and Enhancer of
Chemotherapy Agents - A Patients Perspective. July
2003. This includes the high dose pulsed administration
with taxotere (Beer et al).
3/12/03 Vaccine Page for Provenge updated to indicate
Jack had been on placebo arm.
2/8/03 A new navigation - link bar implemented, various
pages with minor updates and all links verified.
2/8/03 A new page on
liver function tests with an example of a liver
function panel added. Also a new page on
kidney functions has been added.
1/03/03 A new page with all the
second line hormone therapies was added.
12/28/02 The old exisulind page was replaced with a new
Aptosyn® page. This provides an update on this
Bone Integrity page; added a
bisphosphonates page with detailed information on
11/27/02 Added a page on
Aminoglutethimide as a second line hormone
11/26/02 Added a page of
links to prostate cancer websites, including general
cancer and some related websites.
11/18/02 Update of Provenge vaccine trial; a minor
modification to the "Estrogens" section on DES.
Seminars in Urologic Oncology - Recent reports re
Prostate Cancer. This is a review of Seminars in
Urologic Oncology, Volume 20, No. 3, Supplment 1
(August), 2002 which is devoted to prostate cancer.
Effexor for Treating the Pain of Peripheral
Peripheral Neuropathy (polyneuropathy)... a common
side-effect of chemotherapy--is there any solution?
Written by Bill Aishman
Clinical Trials -- Should we Participate?
Combined Hormonal Ablation/Chemotherapy for High Risk
presentation given by Charles E. Myers, MD to the
Kettering Medical Center Prostate Cancer Support Group
on 4/25/02 has been added.
example of impact of taxotere followed by Novantrone
on white blood cell count(WBC) and granulocytes.
Booklet about HRPCa - 7 chapters done so far.
ASCO 2002 (A Patient's View)
Radiation Therapy for HRPCA - spot radiation and
DES and Other Estrogens
Thinking Out-of-the-Box. A patient’s musings about
whether our conventional treatment for advanced prostate
cancer with chemotherapy can be modified to prolong
Nonsteriodal Anti-Inflammatory Drugs in the Treatment of
VEGF and Radiation Therapy
Evaluations of Potential New Therapies for HRPC
Pain Control for HRPC
Can Chemotherapy Extend Survival for HRPC?
A Patients Perspective on Chemotherapy, Part 2
A Patients Perspective on Chemotherapy, Part 1